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Wat volgt is een lijst van wetenschappelijke artikelen die recent gesubsidieerd werden door de Universitaire Stichting. De artikelen zijn gesorteerd op jaar van uitgave en per titel.
Validation of the Erlangen Score Algorithm for Differential Dementia Diagnosis in Autopsy-Confirmed Subjects
Somers, C., Van Broeckhoven, C., Engelborghs, S et al. (2019) Validation of the Erlangen Score Algorithm for Differential Dementia Diagnosis in Autopsy-Confirmed Subjects. Journal of Alzheimer’s Disease 68, 1151–1159. DOI 10.3233/JAD-180563
What Means A Quality Professional–Patient Relationship From The Asthmatic Patients’ Perspective? A Narrative Review Of Their Needs And Expectations
Seret, J. et al. (2019) What Means A Quality Professional–Patient Relationship From The Asthmatic Patients’ Perspective? A Narrative Review Of Their Needs And Expectations, Patient Preference and Adherence, 13: 1951-1960, https://doi.org/10.2147/PPA.S213545
Introduction: Poor treatment adherence among asthmatic patients currently remains a public health challenge. One of the most quoted determinants is the quality of the professional–patient relationship although it has clearly not been fully described.
Purpose: This study aims at deeply exploring asthmatic patients’ needs and expectations about the accompaniment proposed by their healthcare professionals.
Methods: A rigorous narrative review was performed.
Women with infertility complying with and resisting polygyny: an explorative qualitative study in urban Gambia
Dierickx, S. et al.(2019) Women with infertility complying with and resisting polygyny: an explorative qualitative study in urban Gambia. Reproductive Health vol .16, art. 103.
In many low-and middle-income countries women with infertility are often in polygynous marriages (i.e. marriages wherein men have multiple wives). In general, the practice of polygyny is understood to be harmful for women as it would have a negative impact on their health and general well-being. The purpose of this qualitative study is to explore how women with infertility experience polygyny and to understand their decision-making regarding these marriages. In-depth interviews were conducted between October 2017 and May 2018 in urban Gambia.
A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels
Philippaert, K. et al. (2018) A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels. SLAS Discovery.
TRPM5 functions as a calcium-activated monovalent cation-selective ion channel and is expressed in a variety of cell types. Dysfunction of this type of channel has been recently implied in cardiac arrhythmias, diabetes, and other pathologies. Therefore, a growing interest has emerged to develop the pharmacology of these ion channels. We optimized a screening assay based on the thallium flux through the TRPM5 channel and a fluorescent thallium dye as a probe for channel activity.
Klaas M. et al (2018) Acute Effect of Noradrenergic Modulation on Motor Output Adjustment in Men. Medicine & Science in Sports & Exercise.
Purpose: To determine the role of noradrenergic modulation in the control of motor output, we compared the acute effect of Reboxetine (REB), a noradrenaline reuptake inhibitor, to a placebo (PLA) on knee extensors motor performance and cortical and spinal excitability.
Piers, R. et al (2018) Advance care planning in dementia: recommendations for healthcare professionals. BMC Palliative Care, 2018, 17:88, https://doi.org/10.1186/s12904-018-0332-2
Background: Advance care planning (ACP) is a continuous, dynamic process of reflection and dialogue between an individual, those close to them and their healthcare professionals, concerning the individual’s preferences and values concerning future treatment and care, including end-of-life care.
Assessing out-of-pocket expenditures for primary health care: how responsive is the Democratic Republic of Congo health system to providing financial risk protection?
Laokri, S. et al (2018) Assessing out-of-pocket expenditures for primary health care: how responsive is the Democratic Republic of Congo health system to providing financial risk protection? BMC Health Services Research.
Background: The goal of universal health coverage is challenging for chronically under-resourced health systems. Although household out-of-pocket payments are the most important source of health financing in low-income countries, relatively little is known about the drivers of primary health care expenditure and the predictability of the burden associated with high fee-for-service payments.
Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data
Biset, N. et al. (2018) Assessment of medication adherence and responsible use of isotretinoin and contraception through Belgian community pharmacies by using pharmacy refill data. Patient Preference and Adherence 12 153–161.
Purpose: The aims of the study were to evaluate medication adherence and the influencing factors for isotretinoin and contraception (oral, patches, and rings) and to evaluate the concomitant use of contraception and isotretinoin.
Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts
Faict, S. et al. (2018) Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts. Blood Cancer Journal 8:105
Progression of multiple myeloma (MM) is largely dependent on the bone marrow (BM) microenvironment wherein communication through different factors including extracellular vesicles takes place. This cross-talk not only leads to drug resistance but also to the development of osteolysis. Targeting vesicle secretion could therefore simultaneously ameliorate drug response and bone disease. In this paper, we examined the effects of MM exosomes on different aspects of osteolysis using the 5TGM1 murine model.
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion
De Veirman, K. et al. (2018) Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion. Cancer Immunol Res. 5(10), 839–46.
Gilissen, J. et al. How to achieve the desired outcomes of advance care planning in nursing homes: a theory of change BMC Geriatrics (2018, 18:47 DOI 10.1186/s12877-018-0723-5.
Lelubre;, M. et al. (2018) Implementation study of an intermediate medication review in Belgian community pharmacies. Research in Social and Administrative Pharmacy.
Is the socioeconomic status of immigrant mothers in Brussels relevant to predict their risk of adverse pregnancy outcomes?
Sow, M. et al. (2018) Is the socioeconomic status of immigrant mothers in Brussels relevant to predict their risk of adverse pregnancy outcomes? BMC Pregnancy and Childbirth. 2018, 118:422.
Background: Understanding and tackling perinatal health inequities in industrialized countries requires analysing the socioeconomic determinants of adverse pregnancy outcomes among immigrant populations. Studies show that among certain migrant groups, education is not associated with adverse pregnancy outcomes. We aim to extend this analysis to further dimensions of socioeconomic status (SES) and to other settings.
A. Woller & D. Gonze (2018) Modeling clock-related metabolic syndrome due to conflicting light and food cues, Scientific Reports 8:13641 | DOI:10.1038/s41598-018-31804-9.
Gonze, D. et al. (2018) Modeling-Based Investigation of the Effect of Noise in Cellular Systems, Frontiers in Molecular Biosciences, vol 5, April 2018.
Noise is pervasive in cellular biology and inevitably affects the dynamics of cellular processes.
Biological systems have developed regulatory mechanisms to ensure robustness with respect to noise or to take advantage of stochasticity. We review here, through a couple of selected examples, some insights on possible robustness factors and constructive roles of noise provided by computational modeling. In particular, we focus on